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Proceedings Paper

In vitro and ex vivo evaluation of silica-coated super paramagnetic iron oxide nanoparticles (SPION) as biomedical photoacoustic contrast agent
Author(s): Rudolf Alwi; Sergey A. Telenkov; Andreas Mandelis; Timothy Leshuk; Frank Gu; Sulayman Oladepo; Kirk Michaelian; Kristopher Dickie
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Paper Abstract

The employment of contrast agents in photoacoustic imaging has gained significant attention within the past few years for their biomedical applications. In this study, the use of silica-coated superparamagnetic iron oxide (Fe3O4) nanoparticles (SPION) was investigated as a contrast agent in biomedical photoacoustic imaging. SPIONs have been widely used as Food-and-Drug-Administration (FDA)-approved contrast agents for magnetic resonance imaging (MRI) and are known to have an excellent safety profile. Using our frequency-domain photoacoustic correlation technique (“the photoacoustic radar") with modulated laser excitation, we examined the effects of nanoparticle size, concentration and biological medium (e.g. serum, sheep blood) on its photoacoustic response in turbid media (intralipid solution). Maximum detection depth and minimum measurable SPION concentration were determined experimentally. The detection was performed using a single element transducer. The nanoparticle-induced optical contrast ex vivo in dense muscular tissues (avian pectus) was evaluated using a phased array photoacoustic probe and the strong potential of silicacoated SPION as a possible photoacoustic contrast agent was demonstrated. This study opens the way for future clinical applications of nanoparticle-enhanced photoacoustic imaging in cancer therapy.

Paper Details

Date Published: 4 March 2013
PDF: 7 pages
Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85813C (4 March 2013); doi: 10.1117/12.2004592
Show Author Affiliations
Rudolf Alwi, Univ. of Toronto (Canada)
Sergey A. Telenkov, Univ. of Toronto (Canada)
Andreas Mandelis, Univ. of Toronto (Canada)
Timothy Leshuk, Univ. of Waterloo (Canada)
Frank Gu, Univ. of Waterloo (Canada)
Sulayman Oladepo, Natural Resources Canada (Canada)
Kirk Michaelian, Natural Resources Canada (Canada)
Kristopher Dickie, Ultrasonix Medical Corp. (Canada)

Published in SPIE Proceedings Vol. 8581:
Photons Plus Ultrasound: Imaging and Sensing 2013
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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