
Proceedings Paper
High resolution photoacoustic imaging of microvasculature in normal and cancerous bladdersFormat | Member Price | Non-Member Price |
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Paper Abstract
We explored the potential of an emerging laser-based technology, photoacoustic imaging (PAI), for bladder cancer
diagnosis through high resolution imaging of microvasculature in the interior bladder tissues. Images of ex vivo canine
bladders demonstrated the excellent ability of PAI to map three-dimensional microvasculature in optically scattering
bladder tissues. By comparing the results from human bladder specimens affected by cancer to those from the normal
control, the feasibility of PAI in differentiating malignant from benign bladder tissues was explored. The reported
distinctive morphometric characteristics of tumor microvasculature can be seen in the images from cancer samples,
suggesting that PAI may allow in vivo assessment of neoangiogenesis that is closely associated with bladder cancer
generation and progression. By presenting subsurface morphological and physiological information in bladder tissues,
PAI, when performed in a similar way to that in conventional endoscopy, provides an opportunity for improved
diagnosis, staging and treatment guidance of bladder cancer.
Paper Details
Date Published: 4 March 2013
PDF: 6 pages
Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85810J (4 March 2013); doi: 10.1117/12.2004482
Published in SPIE Proceedings Vol. 8581:
Photons Plus Ultrasound: Imaging and Sensing 2013
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)
PDF: 6 pages
Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85810J (4 March 2013); doi: 10.1117/12.2004482
Show Author Affiliations
Zhixing Xie, Univ. of Michigan (United States)
William Roberts, Univ. of Michigan (United States)
Paul L. Carson, Univ. of Michigan (United States)
William Roberts, Univ. of Michigan (United States)
Paul L. Carson, Univ. of Michigan (United States)
Xiaojun Liu, Nanjing Univ. (China)
Chao Tao, Nanjing Univ. (China)
Xueding Wang, Univ. of Michigan (United States)
Chao Tao, Nanjing Univ. (China)
Xueding Wang, Univ. of Michigan (United States)
Published in SPIE Proceedings Vol. 8581:
Photons Plus Ultrasound: Imaging and Sensing 2013
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)
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