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Proceedings Paper

Human organ-on-a-chip BioMEMS devices for testing new diagnostic and therapeutic strategies
Author(s): James F. Leary; Jaehong Key; Pierre-Alexandre Vidi; Christy L. Cooper; Ayeeshik Kole; Lisa M. Reece; Sophie A. Lelièvre
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Paper Abstract

MEMS human “organs-on-a-chip” can be used to create model human organ systems for developing new diagnostic and therapeutic strategies. They represent a promising new strategy for rapid testing of new diagnostic and therapeutic approaches without the need for involving risks to human subjects. We are developing multicomponent, superparamagnetic and fluorescent nanoparticles as X-ray and MRI contrast agents for noninvasive multimodal imaging and for antibody- or peptide-targeted drug delivery to tumor and precancerous cells inside these artificial organ MEMS devices. Magnetic fields can be used to move the nanoparticles “upstream” to find their target cells in an organs-on-achip model of human ductal breast cancer. Theoretically, unbound nanoparticles can then be removed by reversing the magnetic field to give a greatly enhanced image of tumor cells within these artificial organ structures. Using branched PDMS microchannels and 3D tissue engineering of normal and malignant human breast cancer cells inside those MEMS channels, we can mimic the early stages of human ductal breast cancer with the goal to improve the sensitivity and resolution of mammography and MRI of very small tumors and test new strategies for treatments. Nanomedical systems can easily be imaged by multicolor confocal microscopy inside the artificial organs to test targeting and therapeutic responses including the differential viability of normal and tumor cells during treatments. Currently we are using 2-dimensional MEMS structures, but these studies can be extended to more complex 3D structures using new 3D printing technologies.

Paper Details

Date Published: 13 March 2013
PDF: 10 pages
Proc. SPIE 8615, Microfluidics, BioMEMS, and Medical Microsystems XI, 86150A (13 March 2013); doi: 10.1117/12.2004447
Show Author Affiliations
James F. Leary, Purdue Univ. (United States)
Jaehong Key, Purdue Univ. (United States)
Pierre-Alexandre Vidi, Purdue Univ. (United States)
Christy L. Cooper, Purdue Univ. (United States)
Ayeeshik Kole, Purdue Univ. (United States)
Lisa M. Reece, Purdue Univ. (United States)
Sophie A. Lelièvre, Purdue Univ. (United States)

Published in SPIE Proceedings Vol. 8615:
Microfluidics, BioMEMS, and Medical Microsystems XI
Holger Becker; Bonnie L. Gray, Editor(s)

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