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Proceedings Paper

Photoinduced conformational changes of human serum albumin bound to protoporphyrin IX and hemin
Author(s): Sarah C. Rozinek; Lorenzo Brancaleon
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Paper Abstract

Irradiation of porphyrins bound to proteins applies to photodynamic cancer therapy, photo-reduction of water, and the possibility of modifying proteins to impart new functions. Upon binding Protoporphyrin IX (PPIX) and hemin, respectively, to human albumin (HSA), the bound products’ response to low-dose irradiation at pH 7.4 is examined in this study. Spectroscopic data suggests that irradiation of PPIX when bound to HSA causes small secondary and tertiary protein conformational changes. Alternately, sizeable alterations are not seen when hemin bound to HSA is irradiated. This difference indicates a different photophysical mechanism for PPIX than for hemin.

Paper Details

Date Published: 15 February 2013
PDF: 6 pages
Proc. SPIE 8579, Optical Interactions with Tissue and Cells XXIV, 85790G (15 February 2013); doi: 10.1117/12.2004325
Show Author Affiliations
Sarah C. Rozinek, Univ. of Texas at San Antonio (United States)
Lorenzo Brancaleon, Univ. of Texas at San Antonio (United States)

Published in SPIE Proceedings Vol. 8579:
Optical Interactions with Tissue and Cells XXIV
E. Duco Jansen; Robert J. Thomas, Editor(s)

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