Interstitial fluid (ISF) can be transdermally extracted using low-frequency ultrasound and continuous vacuum pressure on skin surface. But the tiny volume of transdermally extracted ISF makes the transdermal extraction, collection, transport, volumetric detection and glucose concentration measurement of the ISF very difficult. Based on a microfluidic chip for transdermally extraction of interstitial fluid and a micro glucose sensor for glucose concentration measurement, a continuous glucose monitoring instrumentby ISF transdermal extraction with minimally invasive way is developed. In the paper, various parts of the device and their interface circuits are designed; the hardware and software of the instrument are built; the simulating experiments of transdermal ISF extraction, collection and volume measurement with full-thickness pig skin are performed using this integrated system; and the functionalities of this device is verified for future clinical application.

Date Published: 9 March 2013
PDF: 11 pages
Proc. SPIE 8615, Microfluidics, BioMEMS, and Medical Microsystems XI, 861519 (9 March 2013); doi: 10.1117/12.2003535

Published in SPIE Proceedings Vol. 8615:
Microfluidics, BioMEMS, and Medical Microsystems XI
Holger Becker; Bonnie L. Gray, Editor(s)