A new borate polymer PAA-ran-PAAPBA that can adsorb glucose specifically is introduced into the glucose measurement based on surface plasmon resonance. Six and twelve layers of borate polymer are bound onto the SPR sensors respectively through the layer-by-layer self-assembly binding method, and then the effect of different layers on the glucose concentration measurement is studied. The experiment is conducted in three concentration ranges, 1~10mg/dL, 10~100mg/dL and 100~1000mg/dL. The Results show that the performance of 12-layer-polymer sensor is better than that of the 6-layer-polymer sensor in the first two ranges, and the measuring result has no big difference in the range of 100~1000mg/d. It indicates that the enhancement of polymer layer on the surface of SPR sensor can dramatically improve the glucose measurement in the low concentration range.

Date Published: 22 March 2013
PDF: 9 pages
Proc. SPIE 8572, Advanced Biomedical and Clinical Diagnostic Systems XI, 85721D (22 March 2013); doi: 10.1117/12.2003508

Published in SPIE Proceedings Vol. 8572:
Advanced Biomedical and Clinical Diagnostic Systems XI
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest M.D., Editor(s)