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Proceedings Paper

Use of functional near-infrared spectroscopy to monitor cortical plasticity induced by transcranial direct current stimulation
Author(s): Bilal Khan; Nathan Hervey; Ann Stowe; Timea Hodics; George Alexandrakis
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Paper Abstract

Electrical stimulation of the human cortex in conjunction with physical rehabilitation has been a valuable approach in facilitating the plasticity of the injured brain. One such method is transcranial direct current stimulation (tDCS) which is a non-invasive method to elicit neural stimulation by delivering current through electrodes placed on the scalp. In order to better understand the effects tDCS has on cortical plasticity, neuroimaging techniques have been used pre and post tDCS stimulation. Recently, neuroimaging methods have discovered changes in resting state cortical hemodynamics after the application of tDCS on human subjects. However, analysis of the cortical hemodynamic activity for a physical task during and post tDCS stimulation has not been studied to our knowledge. A viable and sensitive neuroimaging method to map changes in cortical hemodynamics during activation is functional near-infrared spectroscopy (fNIRS). In this study, the cortical activity during an event-related, left wrist curl task was mapped with fNIRS before, during, and after tDCS stimulation on eight healthy adults. Along with the fNIRS optodes, two electrodes were placed over the sensorimotor hand areas of both brain hemispheres to apply tDCS. Changes were found in both resting state cortical connectivity and cortical activation patterns that occurred during and after tDCS. Additionally, changes to surface electromyography (sEMG) measurements of the wrist flexor and extensor of both arms during the wrist curl movement, acquired concurrently with fNIRS, were analyzed and related to the transient cortical plastic changes induced by tDCS.

Paper Details

Date Published: 8 March 2013
PDF: 12 pages
Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 856560 (8 March 2013); doi: 10.1117/12.2003446
Show Author Affiliations
Bilal Khan, The Univ. of Texas at Arlington (United States)
Nathan Hervey, The Univ. of Texas at Arlington (United States)
Ann Stowe, The Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Timea Hodics, The Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
George Alexandrakis, The Univ. of Texas at Arlington (United States)

Published in SPIE Proceedings Vol. 8565:
Photonic Therapeutics and Diagnostics IX
Andreas Mandelis; Brian Jet-Fei Wong; Anita Mahadevan-Jansen; Henry Hirschberg M.D.; Hyun Wook Kang; Nikiforos Kollias; Melissa J. Suter; Kenton W. Gregory M.D.; Guillermo J. Tearney M.D.; Stephen Lam; Bernard Choi; Steen J. Madsen; Bodo E. Knudsen M.D.; E. Duco Jansen; Justus F. Ilgner M.D.; Haishan Zeng; Matthew Brenner; Laura Marcu, Editor(s)

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