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Proceedings Paper

Novel algorithm for background correction of the quantitative spectroscopic tomography of the biogenic-substances
Author(s): Pradeep K. W. Abeygunawardhana; Wei Qi; Daisuke Kojima; Satoru Suzuki; Akira Nishiyama; Ichirou Ishimaru
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Paper Abstract

The non-invasive blood sugar sensor by using imaging-type 2-dimensional Fourier spectroscopy is to be realized in this work. The spectroscopic imaging, that observes the biological tissue by the dark-field image, can measure the biogenic substance quantitatively such as the glucose concentration. For the quantitative analysis with high accuracy, the correction of the background such as the light-source fluctuation and the phase-shift uncertainty is inevitable issue. Thus, the quantitative band-pass plate on which the grating is locally formed has been already proposed by [1]. In that paper, the diffractive light, whose diffraction angle depends on the wavelength, has been used as the reference light. Object lens is used to narrow down the reference light and narrowed band pass diffraction light is obtained. The changes of imaging intensities with interference phenomenon on whole area of the observation image can be confirmed using the quantitative band pass filter. This paper proposed background correction method of the interferogram in spectroscopic tomography. Correction algorithm mainly contained two parts as light source fluctuation error correction and phase shift error correction.

Paper Details

Date Published: 25 February 2013
PDF: 12 pages
Proc. SPIE 8591, Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics, 85910O (25 February 2013); doi: 10.1117/12.2003402
Show Author Affiliations
Pradeep K. W. Abeygunawardhana, Kagawa Univ. (Japan)
Wei Qi, Kagawa Univ. (Japan)
Daisuke Kojima, Kagawa Univ. (Japan)
Satoru Suzuki, Kagawa Univ. (Japan)
Akira Nishiyama, Faculty of Medicine, Kagawa Univ. (Japan)
Ichirou Ishimaru, Kagawa Univ. (Japan)

Published in SPIE Proceedings Vol. 8591:
Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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