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Proceedings Paper

Preparation and characterization of a drug carrier for hepatocellular carcinoma targeting
Author(s): Yuxiang Ma; Yuqi Chen; Sisi Cui; Juan Zhao; Wei R. Chen; Yueqing Gu
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Paper Abstract

Asialoglycoprotein receptors distributing on the surface of hepatic parenchymal cells could specifically recognize galactose residues. Therefore, galactose residues can be applied in hepatocellar carcinoma targeted therapy through binding to the asialoglycoprotein receptors. A drug carrier containing of near infrared (NIR) fluorescence dye (MPA) and galactose was constructed by covalently conjugation process and named as GAL-MPA. The optical properties, cell viability, cell affinity and in vivo bio-distribution of this drug carrier were evaluated respectively. The results demonstrated that the drug carrier was provided with NIR fluorescence after conjugated with MPA. The low bio-toxicity and high hepatic cells affinity facilitated this drug carrier for in vivo biomedical application. Finally, the in vivo dynamic distribution of GAL-MPA confirmed this drug carrier was a promising candidate for tumor-targeting imaging and therapy.

Paper Details

Date Published: 22 February 2013
PDF: 6 pages
Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820U (22 February 2013); doi: 10.1117/12.2003267
Show Author Affiliations
Yuxiang Ma, China Pharmaceutical Univ. (China)
Yuqi Chen, China Pharmaceutical Univ. (China)
Sisi Cui, China Pharmaceutical Univ. (China)
Juan Zhao, China Pharmaceutical Univ. (China)
Wei R. Chen, Nanjing Univ. of Aeronautics and Astronautics (China)
Yueqing Gu, China Pharmaceutical Univ. (China)

Published in SPIE Proceedings Vol. 8582:
Biophotonics and Immune Responses VIII
Wei R. Chen, Editor(s)

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