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Proceedings Paper

Laser guidance in a microfluidic biochip
Author(s): Wan Qin; Lucas Schmidt; Xiaoqi Yang; Lina Wei; Ting Huang; Julie X. Yuan; Zhen Ma; Xiang Peng; Xiaocong Yuan; Bruce Z. Gao
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Paper Abstract

In this study, we developed a microfluidic biochip to perform laser guidance on two cell types, chick embryonic forebrain neurons and chick embryonic spinal cord neurons. The neurons we obtained from these two cell types have no difference in morphology as observed under a high-magnification microscope. However, when flowing in the microfluidic channel and simultaneously being laser-guided, the two cell types gained quite different guidance velocities under the same experimental conditions. The experimental results demonstrate that different cell types with the same morphology (e.g., size, shape, etc.) can be effectively distinguished from each other by measuring the difference of guidance velocities (the maximum flow velocities minus the initial flow velocities). This technique is expected to provide a new approach to high-throughput, label-free cell sorting with sensitivity.

Paper Details

Date Published: 9 March 2013
PDF: 9 pages
Proc. SPIE 8615, Microfluidics, BioMEMS, and Medical Microsystems XI, 86150S (9 March 2013); doi: 10.1117/12.2003255
Show Author Affiliations
Wan Qin, Clemson Univ. (United States)
Lucas Schmidt, Clemson Univ. (United States)
Xiaoqi Yang, Clemson Univ. (United States)
Lina Wei, Clemson Univ. (United States)
Peking Univ. (China)
Ting Huang, Clemson Univ. (United States)
Peking Univ. (China)
Julie X. Yuan, Clemson Univ. (United States)
Zhen Ma, Univ. of California, Berkeley (United States)
Xiang Peng, Shenzhen Univ. (China)
Xiaocong Yuan, Nankai Univ. (China)
Bruce Z. Gao, Clemson Univ. (United States)

Published in SPIE Proceedings Vol. 8615:
Microfluidics, BioMEMS, and Medical Microsystems XI
Holger Becker; Bonnie L. Gray, Editor(s)

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