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Proceedings Paper

Folate receptor-mediated tumor-targeted upconversion nanocomplex for photodynamic therapy triggered by near-infrared light
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Paper Abstract

In this study, we have prepared tumor-targeted hydrophilic UCNPs by coating folate-modified amphiphilic SOC polymer on the surface of OA-UNCPs through hydrophobic interaction. The produced FASOC-UCNPs have excellent optical properties and good dispersibility in aqueous solution. TEM image and FTIR spectra confirm the successful surface modification of OA-UCNPs and folate-conjugation on the UCNPs. Folate-conjugated UCNPs possess active-targeting ability mediated by FR, compared with passive-targeted SOC-UCNP taken up by tumors via the EPR effect. Singlet oxygen production in cancer cells induced by FASOC-UCNP-ZnPc demonstrates the great potential of the nanocomplex as a novel PDT agent based on UCNPs.

Paper Details

Date Published: 21 February 2013
PDF: 9 pages
Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820A (21 February 2013); doi: 10.1117/12.2003246
Show Author Affiliations
Sisi Cui, China Pharmaceutical Univ. (China)
Haiyan Chen, China Pharmaceutical Univ. (China)
Zhiyu Qian, Nanjing Univ. of Aeronautics and Astronautics (China)
Wei R. Chen, Univ. of Central Oklahoma (United States)
Yueqing Gu, China Pharmaceutical Univ. (China)

Published in SPIE Proceedings Vol. 8582:
Biophotonics and Immune Responses VIII
Wei R. Chen, Editor(s)

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