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Proceedings Paper

Using diffuse optical tomograpy to monitor tumor response to neoadjuvant chemotherapy in breast cancer patients
Author(s): Jacqueline E. Gunther; Emerson Lim; Hyun Keol Kim; Molly Flexman; Mindy Brown; Susan Refrice; Kevin Kalinsky; Dawn Hershman; Andreas H. Hielscher
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Paper Abstract

Breast cancer patients often undergo neoadjuvant chemotherapy to reduce the size of the tumor before surgery. Tumors which demonstrate a pathologic complete response associate with improved disease-free survival; however, as low as 10% of patients may achieve this status. The goal is to predict response to anti-cancer therapy early, so as to develop personalized treatments and optimize the patient’s results. Previous studies have shown that tumor response can be predicted within a few days of treatment initiation. We have developed a diffuse optical tomography (DOT) imaging system for monitoring the response of breast cancer patients to neoadjuvant chemotherapy. Our breast imaging system is a continuous wave system that uses four wavelengths in the near-infrared spectrum (765 nm, 808 nm, 827 nm, and 905 nm). Both breasts are imaged simultaneously with a total of 64 sources and 128 detectors. Three dimensional reconstructions for oxy-hemoglobin concentration ([HbO2]), deoxy-hemoglobin ([Hb]) concentrations, and water are performed using a PDE-constrained multispectral imaging method that uses the diffusion approximation as a model for light propagation. Each patient receives twelve weekly treatments of Taxane followed by four cycles of Doxorubicin and Cyclophosphamide (AC) given every other week. There are six DOT imaging time points: baseline, week 3 and 5 of Paclitaxel, before cycle 1 and 2 of AC, and before surgery. Preliminary results show that there is statistical significance for the percent change of [HbO2], [Hb], [HbT], and percent water at week 2 from the baseline between patients with a pathologic response to chemotherapy.

Paper Details

Date Published: 25 March 2013
PDF: 7 pages
Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85780J (25 March 2013); doi: 10.1117/12.2003111
Show Author Affiliations
Jacqueline E. Gunther, Columbia Univ. (United States)
Emerson Lim, Columbia Univ. (United States)
Hyun Keol Kim, Columbia Univ. (United States)
Molly Flexman, Columbia Univ. (United States)
Mindy Brown, Herbert Irving Comprehensive Cancer Ctr. (United States)
Susan Refrice, Herbert Irving Comprehensive Cancer Ctr. (United States)
Kevin Kalinsky, Columbia Univ. (United States)
Herbert Irving Comprehensive Cancer Ctr. (United States)
Dawn Hershman, Columbia Univ. (United States)
Herbert Irving Comprehensive Cancer Ctr. (United States)
Mailman School of Public Health (United States)
Andreas H. Hielscher, Columbia Univ. (United States)

Published in SPIE Proceedings Vol. 8578:
Optical Tomography and Spectroscopy of Tissue X
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca, Editor(s)

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