In this paper, we demonstrated the use of a spectral domain optical coherence tomography (OCT) in visualizing and quantifying changes in cardiac wall strain and blood-flow velocities under normal and altered hemodynamic conditions in chicken embryos at an early stage of development, focusing on the heart outflow tract (OFT). OCT imaging allowed in vivo evaluation strain and strain rate of the myocardium of the OFT through analyzing the periodic variation of the myocardial wall thickness. We found that alterations in hemodynamic conditions, through OFT banding, Changed strain and blood-flow velocities through the OFT as expected.

Date Published: 26 March 2013
PDF: 8 pages
Proc. SPIE 8593, Optical Methods in Developmental Biology, 859305 (26 March 2013); doi: 10.1117/12.2002999

Published in SPIE Proceedings Vol. 8593:
Optical Methods in Developmental Biology
Andrew M. Rollins; Cecilia Lo; Scott E. Fraser, Editor(s)