
Proceedings Paper
Polyacrylamide based ICG nanocarriers for enhanced fluorescence and photoacoustic imagingFormat | Member Price | Non-Member Price |
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Paper Abstract
Indocyanine green (ICG) is an FDA approved tricarbocyanine dye. This dye, with a strong absorbance in the near
infrared (NIR) region, has been extensively used for fluorescence and photoacoustic imaging in vivo. ICG in its free
form, however, has a few drawbacks that limit its in vivo applications, such as non-targetability, tendency to form
aggregates which changes its optical properties, fast degradation, short plasma lifetime and reduced fluorescence at
body temperature. In order to bypass these inherent drawbacks, we demonstrate a polyacrylamide based nanocarrier
that was particularly designed to carry the negatively charged ICG molecules. These nanocarriers are biodegradable,
biocompatible and can be specifically targeted to any cell or tissue. Using these nanocarriers we avoid all the
problems associated with free ICG, such as degradation, aggregation and short plasma lifetime, and also enhance
demonstrate its ability towards photoacoustics and fluorescence imaging.
Paper Details
Date Published: 21 February 2013
PDF: 8 pages
Proc. SPIE 8596, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V, 85960P (21 February 2013); doi: 10.1117/12.2002921
Published in SPIE Proceedings Vol. 8596:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V
Samuel Achilefu; Ramesh Raghavachari, Editor(s)
PDF: 8 pages
Proc. SPIE 8596, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V, 85960P (21 February 2013); doi: 10.1117/12.2002921
Show Author Affiliations
Aniruddha Ray, Univ. of Michigan (United States)
Hyung Ki Yoon, Univ. of Michigan (United States)
HeeJu Ryu, Univ. of Michigan (United States)
Yong-Eun Koo Lee, Univ. of Michigan (United States)
Hyung Ki Yoon, Univ. of Michigan (United States)
HeeJu Ryu, Univ. of Michigan (United States)
Yong-Eun Koo Lee, Univ. of Michigan (United States)
Gwangseong Kim, Univ. of Michigan (United States)
Xueding Wang, Univ. of Michigan (United States)
Raoul Kopelman, Univ. of Michigan (United States)
Xueding Wang, Univ. of Michigan (United States)
Raoul Kopelman, Univ. of Michigan (United States)
Published in SPIE Proceedings Vol. 8596:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V
Samuel Achilefu; Ramesh Raghavachari, Editor(s)
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