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Proceedings Paper

Monitoring of cycling hypoxia and angiogenesis in FaDu head and neck tumors using a side-firing sensor
Author(s): Bing Yu; Amy Shah; Bingqing Wang; Narasimhan Rajaram; Quanli Wang; Nirmala Ramanujam; Gregory M. Palmer; Mark W. Dewhirst
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Paper Abstract

Many studies have found that hypoxia, particularly cycling hypoxia (CH), can lead to enhanced tumor metastasis and resistance to radiation and chemotherapy. It was also reported that tumor total hemoglobin content (THb), which is directly related to tumor angiogenesis, can have significant impact on tumor’s response to radiation and neoadjuvant chemotherapy. There is a growing demand for technologies to measure tumor hypoxia and angiogenesis temporally in vivo. In this paper, a side-firing fiber optic sensor based on a multi-wavelength frequency-domain near infrared spectroscopy (FD-NIRS) instrument was used to quantify tumor oxygenation and hemoglobin concentrations in nude rats bearing human FaDu head and neck (H and N) tumors during normoxia and forced hyperoxia and cyclic hypoxia. Significant increase (with carbogen gas inhalation) or decrease (with reduced O2 supply) in tumor oxygenation was observed. The studies demonstrated the feasibility of the technology for longitudinal monitoring of H and N tumor’s response to therapy.

Paper Details

Date Published: 25 March 2013
PDF: 8 pages
Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85781E (25 March 2013); doi: 10.1117/12.2002837
Show Author Affiliations
Bing Yu, The Univ. of Akron (United States)
Amy Shah, Duke Univ. (United States)
Bingqing Wang, Duke Univ. (United States)
Narasimhan Rajaram, Duke Univ. (United States)
Quanli Wang, Duke Univ. (United States)
Nirmala Ramanujam, Duke Univ. (United States)
Gregory M. Palmer, Duke Univ. (United States)
Mark W. Dewhirst, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 8578:
Optical Tomography and Spectroscopy of Tissue X
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca, Editor(s)

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