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Proceedings Paper

Evaluation of genetically expressed absorbing proteins using photoacoustic spectroscopy
Author(s): Jan Laufer; Amit Jathoul; Martin Pule; Paul Beard
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Paper Abstract

Genetically expressed contrast agents are of great interest in the life sciences as they allow the study of structure and function of living cells and organisms. However, many commonly used fluorescent proteins present disadvantages when used in mammalian organisms, such as low near-infrared absorption and photostability. In this study, a variety of genetically expressed fluorescent proteins and novel chromoproteins were evaluated using photoacoustic spectroscopy. The results showed that chromoproteins provide stronger photoacoustic signals, better spectral stability, and exhibit less photobleaching than fluorescent proteins.

Paper Details

Date Published: 4 March 2013
PDF: 6 pages
Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85810X (4 March 2013); doi: 10.1117/12.2002497
Show Author Affiliations
Jan Laufer, Charité - Universitätsmedizin Berlin (Germany)
Amit Jathoul, Univ. College London (United Kingdom)
Martin Pule, Univ. College London (United Kingdom)
Paul Beard, Univ. College London (United Kingdom)

Published in SPIE Proceedings Vol. 8581:
Photons Plus Ultrasound: Imaging and Sensing 2013
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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