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Proceedings Paper

Absolute calibration for complex-geometry biomedical diffuse optical spectroscopy
Author(s): Michael A. Mastanduno; Shudong Jiang; Fadi El-Ghussein; Roberta diFlorio-Alexander; Brian W. Pogue; Keith D. Paulsen
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Paper Abstract

We have presented methodology to calibrate data in NIRS/MRI imaging versus an absolute reference phantom and results in both phantoms and healthy volunteers. This method directly calibrates data to a diffusion-based model, takes advantage of patient specific geometry from MRI prior information, and generates an initial guess without the need for a large data set. This method of calibration allows for more accurate quantification of total hemoglobin, oxygen saturation, water content, scattering, and lipid concentration as compared with other, slope-based methods. We found the main source of error in the method to be derived from incorrect assignment of reference phantom optical properties rather than initial guess in reconstruction. We also present examples of phantom and breast images from a combined frequency domain and continuous wave MRI-coupled NIRS system. We were able to recover phantom data within 10% of expected contrast and within 10% of the actual value using this method and compare these results with slope-based calibration methods. Finally, we were able to use this technique to calibrate and reconstruct images from healthy volunteers. Representative images are shown and discussion is provided for comparison with existing literature. These methods work towards fully combining the synergistic attributes of MRI and NIRS for in-vivo imaging of breast cancer. Complete software and hardware integration in dual modality instruments is especially important due to the complexity of the technology and success will contribute to complex anatomical and molecular prognostic information that can be readily obtained in clinical use.

Paper Details

Date Published: 25 March 2013
PDF: 10 pages
Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85780W (25 March 2013); doi: 10.1117/12.2002477
Show Author Affiliations
Michael A. Mastanduno, Thayer School of Engineering at Dartmouth (United States)
Shudong Jiang, Thayer School of Engineering at Dartmouth (United States)
Fadi El-Ghussein, Thayer School of Engineering at Dartmouth (United States)
Roberta diFlorio-Alexander, Geisel School of Medicine (United States)
Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)
Keith D. Paulsen, Thayer School of Engineering at Dartmouth (United States)
Geisel School of Medicine (United States)

Published in SPIE Proceedings Vol. 8578:
Optical Tomography and Spectroscopy of Tissue X
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca, Editor(s)

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