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Proceedings Paper

Label free optimal dynamic discrimination of biological macromolecules
Author(s): S. Afonina; A. Rondi; D. Kiselev; L. Bonacina; J. P. Wolf
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Paper Abstract

The fast development of laser techniques, in particular, the generation of ultrashort femtosecond and even attosecond pulses opens new frontiers and various experimental tools for biomedical applications. The combination of pulse shaping and optimal control is a very promising tool based on coherent manipulation of wavepackets on an ultrafast time scale. It already has successfully been applied for optimal dynamic discrimination (ODD) experiments of biomolecules like free amino acids and flavins which are indistinguishable by spectroscopic means. This approach can be extended toward to label free cellular imaging and detection of chemical or biological substances.

Paper Details

Date Published: 15 March 2013
PDF: 7 pages
Proc. SPIE 8611, Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XIII, 86110F (15 March 2013); doi: 10.1117/12.2002467
Show Author Affiliations
S. Afonina, Univ. of Geneva (Switzerland)
A. Rondi, Univ. of Geneva (Switzerland)
D. Kiselev, Univ. of Geneva (Switzerland)
L. Bonacina, Univ. of Geneva (Switzerland)
J. P. Wolf, Univ. of Geneva (Switzerland)

Published in SPIE Proceedings Vol. 8611:
Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XIII
Alexander Heisterkamp; Peter R. Herman; Michel Meunier; Stefan Nolte, Editor(s)

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