
Proceedings Paper
Wide-field flexible endoscope for simultaneous color and NIR fluorescence image acquisition during surveillance colonoscopyFormat | Member Price | Non-Member Price |
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Paper Abstract
Colorectal cancer (CRC) is the third most common form of cancer and, despite recent declines in both incidence and
mortality, it still remains the second leading cause of cancer-related deaths in the western world. Colonoscopy is the
standard for detection and removal of premalignant lesions to prevent CRC. The major challenges that physicians face
during surveillance colonoscopy are the high adenoma miss-rates and the lack of functional information to facilitate
decision-making concerning which lesions to remove. Targeted imaging with NIR fluorescence would address these
limitations. Tissue penetration is increased in the NIR range while the combination with targeted NIR fluorescent agents
provides molecularly specific detection of cancer cells, i.e. a red-flag detection strategy that allows tumor imaging with
optimal sensitivity and specificity. The development of a flexible endoscopic fluorescence imaging method that can be
integrated with standard medical endoscopes and facilitates the clinical use of this potential is described in this work. A
semi-disposable coherent fiber optic imaging bundle that is traditionally employed in the exploration of biliary and
pancreatic ducts is proposed, since it is long and thin enough to be guided through the working channel of a traditional
video colonoscope allowing visualization of proximal lesions in the colon. A custom developed zoom system magnifies
the image of the proximal end of the imaging bundle to fill the dimensions of two cameras operating in parallel providing
the simultaneous color and fluorescence video acquisition.
Paper Details
Date Published: 22 March 2013
PDF: 6 pages
Proc. SPIE 8572, Advanced Biomedical and Clinical Diagnostic Systems XI, 85720Q (22 March 2013); doi: 10.1117/12.2002320
Published in SPIE Proceedings Vol. 8572:
Advanced Biomedical and Clinical Diagnostic Systems XI
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest M.D., Editor(s)
PDF: 6 pages
Proc. SPIE 8572, Advanced Biomedical and Clinical Diagnostic Systems XI, 85720Q (22 March 2013); doi: 10.1117/12.2002320
Show Author Affiliations
P. Beatriz García-Allende, Helmholtz Zentrum München GmbH (Germany)
Wouter B. Nagengast, Univ. Medisch Ctr. Groningen (Netherlands)
Wouter B. Nagengast, Univ. Medisch Ctr. Groningen (Netherlands)
Jürgen Glatz, Helmholtz Zentrum München GmbH (Germany)
Vasilis Ntziachristos, Helmholtz Zentrum München GmbH (Germany)
Vasilis Ntziachristos, Helmholtz Zentrum München GmbH (Germany)
Published in SPIE Proceedings Vol. 8572:
Advanced Biomedical and Clinical Diagnostic Systems XI
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest M.D., Editor(s)
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