As-synthesized, poly(4-styrenesulfonic acid) (PSS)-coated and SiO₂ coated gold nanorods were taken up by NG108-15 neuronal cells. Exposure to laser light at the plasmon resonance wavelength of gold nanorods was found to trigger the differentiation process in the nanoparticle treated cells. Results were assessed by measuring the maximum neurite length, the number of neurites per neuron and the percentage of neurons with neurites. When the intracellular Ca²⁺ signaling was monitored, evidence of photo-generated transients were recorded without altering other normal cell functions. These results open new opportunities for peripheral nerve regeneration treatments and for the process of infrared nerve stimulation.

Date Published: 15 February 2013
PDF: 11 pages
Proc. SPIE 8579, Optical Interactions with Tissue and Cells XXIV, 85790C (15 February 2013); doi: 10.1117/12.2002291

Published in SPIE Proceedings Vol. 8579:
Optical Interactions with Tissue and Cells XXIV
E. Duco Jansen; Robert J. Thomas, Editor(s)