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Proceedings Paper

Numerical models of cell death in RF ablation with monopolar and bipolar probes
Author(s): Benjamin M. Bright; John A. Pearce
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Paper Abstract

Radio frequency (RF) is used clinically to treat unresectible tumors. Finite element modeling has proven useful in treatment planning and applicator design. Typically isotherms in the middle 50s °C have been used as the parameter of assessment in these models. We compare and contrast isotherms for multiple known Arrhenius thermal damage predictors including collagen denaturation, vascular disruption, liver coagulation and cell death. Models for RITA probe geometries are included in the study. Comparison to isotherms is sensible when the activation time is held constant, but varies considerably when heating times vary. The purpose of this paper is to demonstrate the importance of looking at specific processes and keeping track of the methods used to derive the Arrhenius coefficients in order to study the extremely complex cell death processes due to thermal therapies.

Paper Details

Date Published: 26 February 2013
PDF: 7 pages
Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 858409 (26 February 2013); doi: 10.1117/12.2002137
Show Author Affiliations
Benjamin M. Bright, The Univ. of Texas at Austin (United States)
John A. Pearce, The Univ. of Texas at Austin (United States)

Published in SPIE Proceedings Vol. 8584:
Energy-based Treatment of Tissue and Assessment VII
Thomas P. Ryan, Editor(s)

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