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Proceedings Paper

Gd chelated PANI nanoparticles for combined MR imaging and NIR photothermal cancer therapy
Author(s): Taeksu Lee; Doyeon Bang; Jin-Suck Suh; Yong-Min Huh; Seungjoo Haam
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Paper Abstract

The ultrasensitive and selective diagnosis along with efficient therapy in earliest stage of cancer has been enormously highlighted by a better means to treat the cancer. Herein, Gd (III) chelated polyaniline nanoparticles (GPNPs) was synthesized to be served as a highly T1 enhanced contrast agents and Near-Infrared photothermal therapy probes. In addition, therapeutic antibody was conjugated on the surface of GPNPs for the targeted theragnosis. Fabricated GPNPs significantly reduced the T1 of water protons with as well as represented photothermal ability. The physicochemical properties and biocompatibilities of GNPSs were fully characterized and GPNPs exhibited excellent tumor targeting ability. Consequently, GPNPs exhibited strong potential for efficient diagnosis of cancer in MR imaging and photothermal ablation of epithelial cancer cells.

Paper Details

Date Published: 24 October 2012
PDF: 8 pages
Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85482E (24 October 2012); doi: 10.1117/12.2001967
Show Author Affiliations
Taeksu Lee, Yonsei Univ. (Korea, Republic of)
Doyeon Bang, Yonsei Univ. (Korea, Republic of)
Jin-Suck Suh, Yonsei Univ. College of Medicine (Korea, Republic of)
Yong-Min Huh, Yonsei Univ. College of Medicine (Korea, Republic of)
Seungjoo Haam, Yonsei Univ. (Korea, Republic of)

Published in SPIE Proceedings Vol. 8548:
Nanosystems in Engineering and Medicine
Sang H. Choi; Jin-Ho Choy; Uhn Lee M.D.; Vijay K. Varadan, Editor(s)

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