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Proceedings Paper

Characterizing microscopic morphology in biological tissue with photoacoustic spectrum analysis: feasibility study with simulations and experiments
Author(s): Guan Xu; Irfaan A. Dar; Chao Tao; Xiaojun Liu; Xueding Wang
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Paper Abstract

This study investigates the feasibility of characterizing the microstructures within a biological tissue by analyzing the frequency spectrum of the photoacoustic signal from biological tissue. Hypotheses are derived from theoretical analyses on the relationship between the dimensions as well as concentrations of the optical absorbing sources within the region-of- interest and the linear model fitted to the power spectra of photoacoustic signals. The hypotheses are afterwards validated, following the procedures of ultrasound spectrum analysis, by simulations and experiments with phantoms fabricated by embedding the optically absorbing polyethylene microspheres in porcine gelatin. Quantitatively comparable simulation and experiment results substantiated that photoacoustic spectrum analysis could be a potential tool for characterizing microstructures and optical properties in biological samples.

Paper Details

Date Published: 4 March 2013
PDF: 7 pages
Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85812L (4 March 2013); doi: 10.1117/12.2001943
Show Author Affiliations
Guan Xu, Univ. of Michigan Medical School (United States)
Irfaan A. Dar, Univ. of Michigan (United States)
Chao Tao, Nanjing Univ. (China)
Xiaojun Liu, Nanjing Univ. (China)
Xueding Wang, Univ. of Michigan Medical School (United States)

Published in SPIE Proceedings Vol. 8581:
Photons Plus Ultrasound: Imaging and Sensing 2013
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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