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Proceedings Paper

New developments in clinical CARS
Author(s): Martin Weinigel; Hans Georg Breunig; Marcel Kellner-Höfer; Rainer Bückle; Maxim Darvin; Juergen Lademann; Karsten König
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Paper Abstract

We combined two-photon fluorescence and coherent anti-Stokes Raman scattering (CARS) imaging in a clinical hybrid multiphoton tomograph for in vivo imaging of human skin. The clinically approved TPEF/CARS system provides simultaneous imaging of endogenous fluorophores and non-fluorescent lipids. The Stokes laser for the two-beam configuration of CARS is based on spectral broadening of femtosecond laser pulses in a photonic crystal fiber (PCF). We report on the highly flexible medical TPEF/CARS tomograph MPTflex®-CARS with an articulated arm and first in vivo measurements on human skin.

Paper Details

Date Published: 22 February 2013
PDF: 9 pages
Proc. SPIE 8588, Multiphoton Microscopy in the Biomedical Sciences XIII, 85881E (22 February 2013); doi: 10.1117/12.2001855
Show Author Affiliations
Martin Weinigel, JenLab GmbH (Germany)
Hans Georg Breunig, JenLab GmbH (Germany)
Saarland Univ. (Germany)
Marcel Kellner-Höfer, JenLab GmbH (Germany)
Rainer Bückle, JenLab GmbH (Germany)
Maxim Darvin, Charité Universitätsmedizin Berlin (Germany)
Juergen Lademann, Charité Universitätsmedizin Berlin (Germany)
Karsten König, JenLab GmbH (Germany)
Saarland Univ. (Germany)

Published in SPIE Proceedings Vol. 8588:
Multiphoton Microscopy in the Biomedical Sciences XIII
Ammasi Periasamy; Karsten König; Peter T. C. So, Editor(s)

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