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Proceedings Paper

Monitoring tissue temperature for photothermal cancer therapy based on photoacoustic imaging: a pilot study
Author(s): Zhifang Li; Yubing Liu; Hui Li; Wei R. Chen; Haiyu Chen; Huan Wang
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Paper Abstract

In this study, we proposed photoacoustic imaging to monitor the temperature increase during photothermal therapy, which was carried out by utilizing a continuous wave laser and photoabsorber-enhanced black ink with a absorption peak in the near-infrared optical range. A focusing photoacoustic imaging is interfaced with a nanosecond pulsed laser to image tissue-mimicking phantoms before and after laser irradiation. The results demonstrated that changes in the photoacoustic signal could reflect temperature changes in tissue. More importantly, photoacoustic signal could be used to determine the temperature at the boundary of photoabsorber-enhance tissue during photothermal irradiation. Thus, the photoacoustic imaging could potentially become an effective tool to guide photoabsorber-enhanced photothermal therapy.

Paper Details

Date Published: 22 February 2013
PDF: 7 pages
Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 858209 (22 February 2013); doi: 10.1117/12.2001756
Show Author Affiliations
Zhifang Li, Fujian Normal Univ. (China)
Yubing Liu, Fujian Normal Univ. (China)
Hui Li, Fujian Normal Univ. (China)
Wei R. Chen, Fujian Normal Univ. (China)
Univ. of Central Oklahoma (United States)
Haiyu Chen, Fujian Provincial Hospital (China)
Huan Wang, Fujian Provincial Hospital (China)

Published in SPIE Proceedings Vol. 8582:
Biophotonics and Immune Responses VIII
Wei R. Chen, Editor(s)

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