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Proceedings Paper

Vibration-based photoacoustic tomography
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Paper Abstract

Photoacoustic imaging employing molecular overtone vibration as contrast mechanism opens a new avenue for deep tissue imaging with chemical bond selectivity. Here, we demonstrate vibration-based photoacoustic tomography with an imaging depth on the centimeter scale. To provide sufficient pulse energy at the overtone transition wavelengths, we constructed a compact, barium nitrite crystal-based Raman laser for excitation of 2nd overtone of C-H bond. Using a 5-ns Nd:YAG laser as pumping source, up to 105 mJ pulse energy at 1197 nm was generated. Vibrational photoacoutic spectroscopy and tomography of phantom (polyethylene tube) immersed in whole milk was performed. With a pulse energy of 47 mJ on the milk surface, up to 2.5 cm penetration depth was reached with a signal-to-noise ratio of 12.

Paper Details

Date Published: 4 March 2013
PDF: 9 pages
Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85811M (4 March 2013); doi: 10.1117/12.2001571
Show Author Affiliations
Rui Li, Purdue Univ. (United States)
Justin Rajesh Rajian, Purdue Univ. (United States)
Pu Wang, Purdue Univ. (United States)
Mikhail N. Slipchenko, Purdue Univ. (United States)
Ji-Xin Cheng, Purdue Univ. at West Lafayette (United States)

Published in SPIE Proceedings Vol. 8581:
Photons Plus Ultrasound: Imaging and Sensing 2013
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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