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Proceedings Paper

Gold nanostructure-integrated silica-on-silicon waveguide for the detection of antibiotics in milk and milk products
Author(s): Jayan Ozhikandathil; Simona Badilescu; Muthukumaran Packirisamy
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Paper Abstract

Antibiotics are extensively used in veterinary medicine for the treatment of infectious diseases. The use of antibiotics for the treatment of animals used for food production raised the concern of the public and a rapid screening method became necessary. A novel approach of detection of antibiotics in milk is reported in this work by using an immunoassay format and the Localized Surface Plasmon Resonance property of gold. An antibiotic from the penicillin family that is, ampicillin is used for testing. Gold nanostructures deposited on a glass substrate by a novel convective assembly method were heat-treated to form a nanoisland morphology. The Au nanostructures were functionalized and the corresponding antibody was absorbed from a solution. Solutions with known concentrations of antigen (antibiotics) were subsequently added and the spectral changes were monitored step by step. The Au LSPR band corresponding to the nano-island structure was found to be suitable for the detection of the antibody antigen interaction. The detection of the ampicillin was successfully demonstrated with the gold nano-islands deposited on glass substrate. This process was subsequently adapted for the integration of gold nanostructures on the silica-on-silicon waveguide for the purpose of detecting antibiotics.

Paper Details

Date Published: 24 October 2012
PDF: 8 pages
Proc. SPIE 8412, Photonics North 2012, 84120W (24 October 2012); doi: 10.1117/12.2001473
Show Author Affiliations
Jayan Ozhikandathil, Concordia Univ. (Canada)
Simona Badilescu, Concordia Univ. (Canada)
Muthukumaran Packirisamy, Concordia Univ. (Canada)

Published in SPIE Proceedings Vol. 8412:
Photonics North 2012
Jean-Claude Kieffer, Editor(s)

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