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Proceedings Paper

Development of a new method for cervical cancer cells determination using light scattering spectrum
Author(s): Yan Yang; Rongfeng Jia; Qiyong Sun; Kun Song; Beihua Kong; Xuantao Su
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Paper Abstract

Conventional methods for cervical cancer screening usually employ microscopic observations that may require fluorescence labeling of the cells, which could be time-consuming and expensive. Development of a novel method for cervical cancer cells determination in a rapid, label-free manner may significantly improve the cervical cancer screening technique. Here two-dimensional (2D) light scattering patterns are obtained from yeast cells on a CMOS chip, where laser light is used to excite single cells via fiber-coupling under a microscope. Good agreements between the experimental and Mie theory simulation results convey that 2D light scattering patterns from cervical cancer cells may be obtained upon the apparatus developed here. Mie theory simulations on simplified normal and cancerous cervical cells show that side scattering spectrum may be used for cervical cancer cells screening. Future experiments further convincing the 2D light scattering method proposed here may bring up a powerful technique that has profound applications in cervical cancer cell determination.

Paper Details

Date Published: 24 October 2012
PDF: 8 pages
Proc. SPIE 8412, Photonics North 2012, 841205 (24 October 2012); doi: 10.1117/12.2001241
Show Author Affiliations
Yan Yang, Shandong Univ. (China)
Rongfeng Jia, Shandong Univ. (China)
Qiyong Sun, Shandong Univ. (China)
Kun Song, Qilu Hospital of Shandong Univ. (China)
Beihua Kong, Qilu Hospital of Shandong Univ. (China)
Xuantao Su, Shandong Univ. (China)

Published in SPIE Proceedings Vol. 8412:
Photonics North 2012
Jean-Claude Kieffer, Editor(s)

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