Share Email Print

Proceedings Paper

Assessments of urine cofilin-1 in patients hospitalized in the intensive care units with acute kidney injury
Author(s): Yi-Jang Lee; Cheng-Han Chao; Ying-Feng Chang; Chien Chou
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

The actin depolymerizing factor (ADF)/cofilin protein family has been reported to be associated with ischemia induced renal disorders. Here we examine if cofilin-1 is associated with acute kidney injury (AKI). We exploited a 96-well based fiber-optic biosensor that uses conjugated gold nanoparticles and a sandwich immunoassay to detect the urine cofilin-1 level of AKI patients. The mean urine cofilin-1 level of the AKI patients was two-fold higher than that of healthy adults. The receiver operating characteristic (ROC) curve showed that cofilin-1 is a potential biomarker for discriminating AKI patients from healthy adults for intensive care patients.

Paper Details

Date Published: 21 February 2013
PDF: 5 pages
Proc. SPIE 8582, Biophotonics and Immune Responses VIII, 85820N (21 February 2013);
Show Author Affiliations
Yi-Jang Lee, National Yang-Ming Univ. (Taiwan)
Cheng-Han Chao, National Taiwan Univ. Hospital (Taiwan)
National Tsing Hua Univ. (Taiwan)
Ying-Feng Chang, Chang Gung Univ. (Taiwan)
Chien Chou, Chang Gung Univ. (Taiwan)

Published in SPIE Proceedings Vol. 8582:
Biophotonics and Immune Responses VIII
Wei R. Chen, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?