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Proceedings Paper

Tight neurovascular coupling in a rat model of quasi-periodic interictal spiking using multispectral optical imaging
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Paper Abstract

The hemodynamic responses to 4-aminopyridine (4-AP) induced focal epileptic spikes and electrical stimulations are compared in a rat model. Nonlinearities are quantified with biophysical models. Supranormal oxygen consumption from epileptic spikes is inferred. In one recording, interictal spikes followed an almost periodic pattern. Such rhythmic spiking is a well-documented phenomenon in electrophysiological studies, but the hemodynamics correlates have been less studied. Spikes occurred every 12.5 ± 1.0 s. Peaks in total hemoglobin (HbT), a proxy for regional cerebral blood volume, followed spikes by 2.6 ± 0.3 s. Troughs in HbT preceded spikes by 1.68 ± 1.2 s. The narrowness of this distribution is surprising. From it, one may derive a significant but paradoxical fall in HbT several seconds before the spikes, but which this decrease in HbT is better interpreted as being due to the interictal spike that occurred before.

Paper Details

Date Published: 23 October 2012
PDF: 6 pages
Proc. SPIE 8412, Photonics North 2012, 841203 (23 October 2012); doi: 10.1117/12.2000717
Show Author Affiliations
Philippe Pouliot, Ecole Polytechnique de Montréal (Canada)
Montréal Heart Institute (Canada)
Van Tri Truong, Ecole Polytechnique de Montréal (Canada)
Cong Zhang, Ecole Polytechnique de Montréal (Canada)
Simon Dubeau, Ecole Polytechnique de Montréal (Canada)
Frédéric Lesage, Ecole Polytechnique de Montréal (Canada)
Montréal Heart Institute (Canada)

Published in SPIE Proceedings Vol. 8412:
Photonics North 2012
Jean-Claude Kieffer, Editor(s)

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