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Proceedings Paper

Comparison of RNFL thickness and RPE-normalized RNFL attenuation coefficient for glaucoma diagnosis
Author(s): K. A. Vermeer; J. van der Schoot; H. G. Lemij; J. F. de Boer
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Paper Abstract

Recently, a method to determine the retinal nerve fiber layer (RNFL) attenuation coefficient, based on normalization on the retinal pigment epithelium, was introduced. In contrast to conventional RNFL thickness measures, this novel measure represents a scattering property of the RNFL tissue. In this paper, we compare the RNFL thickness and the RNFL attenuation coefficient on 10 normal and 8 glaucomatous eyes by analyzing the correlation coefficient and the receiver operator curves (ROCs). The thickness and attenuation coefficient showed moderate correlation (r=0.82). Smaller correlation coefficients were found within normal (r=0.55) and glaucomatous (r=0.48) eyes. The full separation between normal and glaucomatous eyes based on the RNFL attenuation coefficient yielded an area under the ROC (AROC) of 1.0. The AROC for the RNFL thickness was 0.9875. No statistically significant difference between the two measures was found by comparing the AROC. RNFL attenuation coefficients may thus replace current RNFL thickness measurements or be combined with it to improve glaucoma diagnosis.

Paper Details

Date Published: 26 March 2013
PDF: 6 pages
Proc. SPIE 8567, Ophthalmic Technologies XXIII, 85671D (26 March 2013); doi: 10.1117/12.2000664
Show Author Affiliations
K. A. Vermeer, The Rotterdam Eye Hospital (Netherlands)
J. van der Schoot, The Rotterdam Eye Hospital (Netherlands)
H. G. Lemij, The Rotterdam Eye Hospital (Netherlands)
J. F. de Boer, The Rotterdam Eye Hospital (Netherlands)
Vrije Univ. Amsterdam (Netherlands)

Published in SPIE Proceedings Vol. 8567:
Ophthalmic Technologies XXIII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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