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Proceedings Paper

Applications of a novel hemodynamic model to functional brain studies with fNIRS and fMRI
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Paper Abstract

We report time-domain applications of a new hemodynamic model by Fantini [1] that yields analytic expressions for signals that are measurable with hemodynamic-based neuroimaging techniques such as functional near-infrared spectroscopy (fNIRS) and functional magnetic resonance imaging (fMRI). We show how the model can be used to predict the perturbations in cerebral blood volume (CBV), blood flow (CBF), and metabolic rate of oxygen (CMRO2) that account for the initial dip and post-stimulus undershoot that have been reported in the fMRI and fNIRS literature. Furthermore, we have used data from the literature to perform a comparison between measured fNIRS and fMRI signals and the corresponding signals predicted by the new hemodynamic model. Results showed an excellent agreement between the model predictions and the reported measured data.

Paper Details

Date Published: 25 March 2013
PDF: 8 pages
Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 857806 (25 March 2013); doi: 10.1117/12.2000551
Show Author Affiliations
Jana M. Kainerstorfer, Tufts Univ. (United States)
Michele L. Pierro, Tufts Univ. (United States)
Bertan Hallacoglu, Tufts Univ. (United States)
Angelo Sassaroli, Tufts Univ. (United States)
Sergio Fantini, Tufts Univ. (United States)

Published in SPIE Proceedings Vol. 8578:
Optical Tomography and Spectroscopy of Tissue X
Bruce J. Tromberg; Arjun G. Yodh; Eva Marie Sevick-Muraca, Editor(s)

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