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Proceedings Paper

In vivo cw Nd:YAG volatilization: quantification using surface temperature measurements and histology
Author(s): Claire Beacco; Serge R. Mordon; Valerie A. Mitchell; Jean Marc Brunetaud
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Paper Abstract

We performed an in-vivo study to identify and quantify the steps of volatilization. In all experiments, an infrared camera was used to record surface temperature during shot induced on in-vivo rat liver by a cw Nd:YAG laser. In a first group (5 animals), irradiation time varied from 1 to 9 seconds, power equals 20 watts and spot diameter equals 4 mm. Samples were immediately removed and fixed. In the second group (6 animals), time was fixed to 7 seconds. Liver from 2 animals was removed and fixed respectively at J0, J + 12 and J + 19. All sections were observed under microscope and damage depths measured. For irradiation time from 1 to 4 s, we noted blanching, temperature remained below 100 degree(s)C and damage depth was 850 micrometers . For durations from 5 to 7 s, we noted a dark red spot, temperature reached 145 degree(s)C and damage depth increased from 1800 to 5000 micrometers . For longer irradiation times, we noted coagulation, pop-corn effect, carbonization and tissue removal for 9 s. Damage depth was 5000 micrometers . Delayed histology showed that the necrosis was progressively separated from healthy tissue by a layer of conjunctive tissue. In-vivo volatilization could be described in 3 steps: coagulation, pop-corn effect, and tissue removal. We identified a relation between quantitative data and histological modifications.

Paper Details

Date Published: 18 January 1995
PDF: 11 pages
Proc. SPIE 2323, Laser Interaction with Hard and Soft Tissue II, (18 January 1995); doi: 10.1117/12.199185
Show Author Affiliations
Claire Beacco, INSERM (France)
Serge R. Mordon, INSERM (France)
Valerie A. Mitchell, INSERM (France)
Jean Marc Brunetaud, INSERM (France)

Published in SPIE Proceedings Vol. 2323:
Laser Interaction with Hard and Soft Tissue II
Hans Joerg Albrecht; Guy P. Delacretaz; Thomas H. Meier; Rudolf W. Steiner; Lars Othar Svaasand; Martin J. C. van Gemert, Editor(s)

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