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Proceedings Paper

Light distribution in the endometrium during photodynamic therapy
Author(s): Sten Madsen; Lars Othar Svaasand; Mathias K. Fehr; Yona Tadir M.D.; Phat Ngo; Bruce J. Tromberg
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Paper Abstract

Hysterectomy is the most common major operation performed in the United States with dysfunctional uterine bleeding being a major indication. Endometrial destruction by photodynamic therapy (PDT) has been suggested as a possible alternative to invasive surgical procedures for abnormal uterine bleeding due to benign changes. Effective destruction of the endometrium during PDT requires a sufficient amount of light to be delivered to the entire endometrium in a reasonable time. To satisfy these criteria, we have developed a trifurcated optical applicator consisting of three cylindrical diffusing fibers. The applicator was inserted into freshly excised, intact human uteri and the optical distribution was measured with an isotropic fiber probe at various locations in the uterus. The results were in good agreement with the predictions of a mathematical model based on diffusion theory. The results indicate that irradiation of the endometrium by the trifurcated applicator can destroy tissue to a depth of 4 mm given an optical power of 100 mW per cm of diffusing tip (100 mW/cm) for an exposure time of less than 20 minutes.

Paper Details

Date Published: 18 January 1995
PDF: 9 pages
Proc. SPIE 2323, Laser Interaction with Hard and Soft Tissue II, (18 January 1995); doi: 10.1117/12.199184
Show Author Affiliations
Sten Madsen, Beckman Laser Institute and Medical Clinic (United States)
Lars Othar Svaasand, Univ. of Trondheim (Norway)
Mathias K. Fehr, Univ. Hospital of Zurich (Switzerland)
Yona Tadir M.D., Beckman Laser Institute and Medical Clinic (United States)
Phat Ngo, Beckman Laser Institute and Medical Clinic (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (United States)

Published in SPIE Proceedings Vol. 2323:
Laser Interaction with Hard and Soft Tissue II
Hans Joerg Albrecht; Guy P. Delacretaz; Thomas H. Meier; Rudolf W. Steiner; Lars Othar Svaasand; Martin J. C. van Gemert, Editor(s)

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