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Proceedings Paper

Photophysical characterization of far-red absorbing photosensitizers in cyclodextrin solutions
Author(s): Beate Roeder; Carsten Zimmermann; Ralf Herter
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Paper Abstract

One of the most important problems for clinical use of photodynamic therapy is the selective accumulation of photosensitizer molecules by the tumor tissue. Possibly cyclodextrins could be used to solubilize and transport hydrophobic dyes to the target. Until now it has not been investigated to what extent the dye-cyclodextrin complexation alters the photophysical properties of the dye molecules important for their photodynamic activity. For this reason we investigated the behavior of three sensitizers belonging to different chemical classes: pheophorbide a, octa-(alpha) -butyloxy-Zn-phthalocyanine, and tetra-tert-butyl-Zn- naphthalocyanine in cyclodextrin solutions.

Paper Details

Date Published: 12 January 1995
PDF: 12 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199181
Show Author Affiliations
Beate Roeder, Humboldt Univ. Berlin (Germany)
Carsten Zimmermann, Humboldt Univ. Berlin (Germany)
Ralf Herter, Humboldt Univ. Berlin (Germany)

Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)

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