
Proceedings Paper
Photodynamic therapy of human skin tumors using topical application of 5-aminolevulinic acid, dimethylsulfoxide (DMSO), and edetic acid disodium salt (EDTA)Format | Member Price | Non-Member Price |
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Paper Abstract
The results of photodynamic therapy (PDT) in 48 patients bearing basal cell carcinoma (BCC) and 7 patients with squamous cell carcinoma (SCC) of the skin are described. Five- aminolevulinic acid (5-ALA) was applied topically in two formulations. The first formulation contained 20% of 5-ALA in a base cream, and the second formulation (5-ALA composite cream), contained an additional 2% of dimethylsulfoxide (DMSO) and 2% of edetic acid disodium salt (EDTA). The creams were left on the skin for 2 - 5 hours. Production of protoporphyrin (PP) was measured in situ by a laser-induced fluorescence (LIF) method. The results of fluorescence measurement clearly indicate that PP accumulation in tumors induced by the 5-ALA composite cream was markedly higher than that induced by the 5-ALA cream. The tumors were light-irradiated (600 - 720 nm) after 4 - 5 hours of cream applications, using the light delivery system Versa-Light by a light dose of 100 J/cm2. The clinically superficial BCC tumors were highly responsive to PDT; the overall result in BCC patients was an 85.4% complete response. Histological examination showed an initial edematous reaction, followed by necrosis and complete disappearance of the tumor. The superficial SCC tumors showed a 100% complete response after PDT. The ulcerated nodular SCC showed partial responses.
Paper Details
Date Published: 12 January 1995
PDF: 6 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199178
Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)
PDF: 6 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199178
Show Author Affiliations
Arie Orenstein M.D., Sheba Medical Ctr. (Israel)
Gennady Kostenich, Sheba Medical Ctr. (Israel)
H. Tsur, Sheba Medical Ctr. (Israel)
Gennady Kostenich, Sheba Medical Ctr. (Israel)
H. Tsur, Sheba Medical Ctr. (Israel)
Leonid Roitman, Bar-Ilan Univ. (Israel)
Benjamin Ehrenberg, Bar-Ilan Univ. (Israel)
Zvi Malik, Bar-Ilan Univ. (Israel)
Benjamin Ehrenberg, Bar-Ilan Univ. (Israel)
Zvi Malik, Bar-Ilan Univ. (Israel)
Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)
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