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Proceedings Paper

Quantitative data on blood flow during tumor PDT obtained by laser Doppler spectroscopy in the hen's egg test system
Author(s): Anja Vervoorts; H. Achim Rood; Marcus Klotz; Joerg G. Moser; Martin Rosenbruch
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Paper Abstract

Oxygen supply is the most important requirement of type II photodynamic reactions. Prerequisite in photodynamic tumor therapy is an intact tumor blood flow during irradiation. Most photosensitizers destroy tumor vessels due to accumulation in endothelial cells. As a prerequisite to develop novel photosensitizing drugs an in-vivo test system is required to quantitatively assess for inertness of those sensitizers to the blood supply. We adapted and further developed a system capable of measuring the relative oxygen supply to heterotransplanted tumors on the yolk sac membrane (YSM) of fertilized chicken eggs.

Paper Details

Date Published: 12 January 1995
PDF: 9 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199175
Show Author Affiliations
Anja Vervoorts, Heinrich-Heine-Univ. (Germany)
H. Achim Rood, Heinrich-Heine-Univ. (Germany)
Marcus Klotz, Klotz Analytical Registration Techniques (Germany)
Joerg G. Moser, Heinrich-Heine-Univ. (Germany)
Martin Rosenbruch, Bayer AG (Germany)

Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)

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