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Proceedings Paper

Experimental studies of combination of PDT and tumor chemotherapy or 60Co irradiation
Author(s): Janina Didziapetriene; Grazina Prasmickiene; Dalija Sukeliene; Ricardas Rotomskis; Giedre Streckyte; Vydmantas Atkocius; Laima Staciokiene; Valerijus Smilgevicius
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Paper Abstract

We present experimental results obtained by combining photodynamic therapy (PDT) with tumor chemotherapy or radiotherapy. Dimethoxyhematoporphyrin (DMHp) and photosan (PS) were used as photosensitizers, pharanoxi and vincristine as antitumor drugs. The therapeutic effect of the combination of PDT and antitumor drugs (pharanoxi, vincristine) slightly increases as compared to the treatment of PDT or antitumor drug alone. The additive therapeutic effect is achieved under the combination of PDT and 60Co irradiation. It seems that the sensitizers DMHp and PS regulate lipid peroxidation in blood serum of experimental animals, which becomes more active under the influence of alkylating antitumor drugs. Therefore, they could protect an organism from negative influence of tumor chemotherapy.

Paper Details

Date Published: 12 January 1995
PDF: 8 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199172
Show Author Affiliations
Janina Didziapetriene, Lithuanian Oncology Ctr. (Lithuania)
Grazina Prasmickiene, Lithuanian Oncology Ctr. (Lithuania)
Dalija Sukeliene, Lithuanian Oncology Ctr. (Lithuania)
Ricardas Rotomskis, Vilnius Univ. (Lithuania)
Giedre Streckyte, Vilnius Univ. (Lithuania)
Vydmantas Atkocius, Vilnius Univ. (Lithuania)
Laima Staciokiene, Vilnius Univ. (Lithuania)
Valerijus Smilgevicius, Vilnius Univ. (Lithuania)


Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)

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