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Proceedings Paper

Influence of photodynamic therapy on the delay of metastasis development in Lewis lung carcinoma
Author(s): Vanya Mantareva; Kroum Kassabov; Maria Shopova; Silke Muller; Dieter Woehrle
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Paper Abstract

As it is known the tumor model Lewis lung carcinoma (LLC) is inclined to form metastases very early after its implantation. Although photodynamic therapy (PDT) of tumors is a local method, we studied its influence on the development of lung metastases in LLC bearing C57B1/6 mice after tumor implantation. The used photosensitizer was a newly synthesized Zn(II)-naphthalocyanine (tetrabenzylamidotetranaphtho (2, 3-b:2', 3'-g: 2', 3' - 1:2'', 3''-q) porphyrazinatozinc) incorporated into DPPC-liposomes and excited with monochromatic light at its absorption maximum (lambda) exc 774 nm). The appearance of metastases in the animal lungs was evaluated according to the method of Pal, et al. Fourteen days after LLC implantation the tumor diameter for the treated mice was 6 mm (a week after PDT) towards 13.6 mm for the untreated. The percentage of surviving animals was 100 for the treated towards 0 for the untreated (a month after the implantation). Fourteen days after LLC implantation only 25% from the treated animals developed metastases to 75% from the untreated. The summary metastasis volume was 4.5 times smaller for the treated than the untreated mice. In conclusion we consider that the used Zn(II)-naphthalocyanine could be an effective photosensitizer for LLC treatment and although the PDT-method is a local one it could influence the process of metastasis development.

Paper Details

Date Published: 12 January 1995
PDF: 9 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199167
Show Author Affiliations
Vanya Mantareva, Institute of Organic Chemistry (Bulgaria)
Kroum Kassabov, National Ctr. of Oncology (Bulgaria)
Maria Shopova, Institute of Organic Chemistry (Bulgaria)
Silke Muller, Univ. Bremen (Germany)
Dieter Woehrle, Univ. Bremen (Germany)

Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)

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