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Proceedings Paper

Synthesis and properties of ether-bonded porphyrin-chlorin dimers
Author(s): Andrei F. Mironov; Ekaterina G. Levinson
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Paper Abstract

Synthesis of a series of model ether-bonded porphyrin-chlorin dimers with graded amphiphility as advantageous sensitizers for photodynamic therapy has been performed. Two macrocycles have been condensed via porphyrin-o1 trifluoroacetate. Hydroxyoctaethylporphyrin has been chosen as hydrophobic moiety and purpurin 18 derivatives have been chosen as hydrophilic components. New dimers have intense absorption maxima in the range of 665 - 700 nm, as well as weaker peaks at 622 - 624 nm that allows us to work with these sensitizers following new laser techniques which permit deeper light penetration into the tissues. The presence of hydrophobic octaethylporphyrin moiety and hydrophilic tri-carboxychlorin part in one molecule allows us to select structure with optimal amphiphility for sensitizer penetration and accumulation.

Paper Details

Date Published: 12 January 1995
PDF: 9 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199161
Show Author Affiliations
Andrei F. Mironov, M.V. Lomonosov Moscow State Academy of Fine Chemical Technology (Russia)
Ekaterina G. Levinson, M.V. Lomonosov Moscow State Academy of Fine Chemical Technology (Russia)

Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)

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