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Proceedings Paper

Chlorin-type photosensitizers derived from vinyl porphyrins
Author(s): Daniel Brault; B. Aveline; O. Delgado; Christine Vever-Bizet
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Paper Abstract

The reaction of singlet oxygen with vinyl porphyrins, which was first described in the case of protoporphyrin, is reinvestigated as a route to chlorin type molecules. Various dicarboxylic chlorins were thus prepared and characterized for their chemical and photosensitizing properties. All of them efficiently photosensitize the production of singlet oxygen. Some of these compounds might be formed during photodynamic therapy with hematoporphyrin derivative or Photofrin. Their biological relevance is discussed.

Paper Details

Date Published: 12 January 1995
PDF: 7 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199160
Show Author Affiliations
Daniel Brault, Mueseum National d'Histoire Naturelle (France)
B. Aveline, INSERM (France)
O. Delgado, INSERM (France)
Christine Vever-Bizet, INSERM (France)

Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)

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