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Proceedings Paper

Comparative analysis of different phthalocyanine photosensitizers for experimental PDT of cancer
Author(s): Maria G. Galpern; Irina Novozhilova; Galina Sokolova; Georgy N. Vorozhtsov; Natalia N. Zharkova; Dmitrij N. Kozlov; Victor V. Sokolov; Garry M. Sukhin
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Paper Abstract

Preliminary biological screening has resulted in data about the considerable difference in photodynamic activity of sulfuric acids of aluminum phthalocyanine and their different salts have been obtained. The photosensitizers have been introduced intravenously in laboratory male mice 24 hours before direct laser irradiation of the liver area through the front abdominal side. Seven-day Erlich carcinomas with a diameter of 0.5 cm transplanted hypodermically to the mice have been used as an experimental tumor model. Obtained data of preliminary biological screening on photodynamic activity and tumor selectivity of different photosensitizers has been confirmed by direct experiments on the PDT experimental tumor in mice with the use of a laser system on the basis of yttrium aluminate with the wavelength 670 nm. Preparations have been introduced as a solution 2 mg/ml intravenous with a dose 10 mg/kg 48 hours before irradiation with the laser. Irradiation dose was 90 J with a spot diameter of 1 cm. Efficiency of anti-tumor PDT has been estimated by sight and with morphological study of the material.

Paper Details

Date Published: 12 January 1995
PDF: 4 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199154
Show Author Affiliations
Maria G. Galpern, Moscow Institute of Organic Intermediates and Dyes (Russia)
Irina Novozhilova, Moscow Institute of Organic Intermediates and Dyes (Russia)
Galina Sokolova, Moscow Institute of Organic Intermediates and Dyes (Russia)
Georgy N. Vorozhtsov, Moscow Institute of Organic Intermediates and Dyes (Russia)
Natalia N. Zharkova, General Physics Institute (Russia)
Dmitrij N. Kozlov, General Physics Institute (Russia)
Victor V. Sokolov, P.A. Hertzen Moscow Research Oncology Institute (Russia)
Garry M. Sukhin, P.A. Hertzen Moscow Research Oncology Institute (Russia)

Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)

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