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Proceedings Paper

Discrepancy between photodynamic injuries and pheophorbide A accumulation in digestive tissues
Author(s): S. Evrard; M. Koenig; C. Damge; Jacques Marescaux; M. Aprahamian
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Paper Abstract

This report describes the discrepancy between pheophorbide A (PH-A) localization and photodynamically induced necrosis for the digestive tract. After an IV 9 mg/Kg-1 sensitization, the dye was caught by the whole digestive tract and its inherent vessels, as shown by fluorescence microscopy. The dye fluorescence disappeared within 24 h from the stomach and the jejunum. It remained high in the pancreas, the portal vein, the bile duct, the arteries and the duodenal mucosae. A light dose, 660 nm, 100 J/cm-2, 24 h after Ph-A sensitization, induced a necrosis of the duodenal mucosae. The pancreas and the hepatic pedicle were relatively unaffected by photodynamic therapy (PDT). The duodenal response to PDT results logically from its selective PH-A retention. But hepatic pedicule and pancreas immunities for PDT involve either protecting singlet oxygen scavengers or photosensitizer quenchers.

Paper Details

Date Published: 12 January 1995
PDF: 8 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199146
Show Author Affiliations
S. Evrard, Hopitaux Universitaires (France)
M. Koenig, Hopitaux Universitaires (France)
C. Damge, Hopitaux Universitaires (France)
Jacques Marescaux, Hopitaux Universitaires (France)
M. Aprahamian, Hopitaux Universitaires (France)

Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)

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