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Proceedings Paper

Comparative in vitro and in vivo measurements of hydrophilic and hydrophobic porphyrins
Author(s): Herbert Schneckenburger; Reinhard Sailer; Michael H. Gschwend; Karin Kunzi-Rapp; Angelika C. Rueck; Wolfgang S. L. Strauss
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Paper Abstract

The photosensitizers uroporphyrin III (UP III), coproporphyrin III (CP III), and protoporphyrin IX (PP IX) were examined with respect to their composition (by different molecular species), uptake and distribution in cells and tissues, intracellular pH value, cytotoxicity and formation of photoproducts. Whereas hydrophilic UP III and CP III were characterized by low cytotoxicity and preferential accumulation in lysosomes, hydrophobic PP IX was found to be rather cytotoxic and mainly localized in cellular membranes. Rapid uptake in tissues and some preferential location in tumor cells were detected for hydrophobic photosensitizers.

Paper Details

Date Published: 12 January 1995
PDF: 10 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199133
Show Author Affiliations
Herbert Schneckenburger, Univ. Ulm and Fachhochschule Aalen (Germany)
Reinhard Sailer, Univ. Ulm (Germany)
Michael H. Gschwend, Univ. Ulm (Germany)
Karin Kunzi-Rapp, Univ. Ulm (Germany)
Angelika C. Rueck, Univ. Ulm (Germany)
Wolfgang S. L. Strauss, Univ. Ulm (Germany)

Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)

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