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Proceedings Paper

Carrier systems in PDT: on the way to novel antitumor drugs
Author(s): Joerg G. Moser; Anja Ruebner-Heuermann; Peter Oehr; Hugo Scheer; Anja Vervoorts; Sonja Andrees
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Paper Abstract

A novel mode to apply photosensitizing drugs specifically to tumor tissue using the principles of polyphasic tumor therapies is outlined. Key compounds are tumor specific functionalized antibodies with reduced immunogenicity. These bind to drug inclusion complexes in a multiplicative manner. Drug inclusion complexes are designed on the basis of tethered functionalized (beta) -cyclodextrin dimers with maximum affinity to porphyrinoid photosensitizers forming monomeric chlathrates. To enhance porphyrin-cyclodextrin interaction peripheral groups of the porphyrin have to be chemically modified. The development of the method is not yet completed. First results are demonstrated.

Paper Details

Date Published: 12 January 1995
PDF: 8 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199131
Show Author Affiliations
Joerg G. Moser, Heinrich-Heine-Univ. (Germany)
Anja Ruebner-Heuermann, Heinrich-Heine-Univ. (Germany)
Peter Oehr, Heinrich-Heine-Univ. (Germany)
Hugo Scheer, Ludwig-Maximilians-Univ. (Germany)
Anja Vervoorts, Heinrich-Heine-Univ. (Germany)
Sonja Andrees, Heinrich-Heine-Univ. (Germany)

Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)

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