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Proceedings Paper

Synthetic approaches to long-wavelength photosensitizers for photodynamic therapy and their preliminary biological activity
Author(s): R. K. Pandey; Nadine Jagerovic; Thomas J. Dougherty; Kevin M. Smith
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Paper Abstract

The chlorophyll-a degradation product, purpurin-18 methyl ester (4), was converted into a series of new bacteriochlorins (18)-(20). These stable bacteriochlorins have strong long- wavelength absorptions > 800 nm, and were tested for in vivo photosensitizing activity using the standard screening system of DBA/2 mice bearing transplanted SMT/F tumors. In preliminary screening, among the photosensitizers tested so far, bacteriochlorins (19) and (20) have shown promising anti-tumor activity. Preliminary attempts are described, using photo- Fenton chemistry, to synthesize photosensitizers which display both Type-I and Type-II photochemical behavior.

Paper Details

Date Published: 12 January 1995
PDF: 11 pages
Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); doi: 10.1117/12.199130
Show Author Affiliations
R. K. Pandey, Texas A&M Univ. (United States)
Nadine Jagerovic, Univ. of California/Davis (United States)
Thomas J. Dougherty, Roswell Park Cancer Institute (United States)
Kevin M. Smith, Univ. of California/Davis (United States)

Published in SPIE Proceedings Vol. 2325:
Photodynamic Therapy of Cancer II
Daniel Brault; Giulio Jori; Johan Moan; Benjamin Ehrenberg, Editor(s)

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