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Proceedings Paper

Fluorescence spectroscopy in combination with reflectance measurements in human skin examination: what for and how
Author(s): Sergei R. Utz M.D.; Yurii P. Sinichkin; Igor Victorovich Meglinski; Helena A. Pilipenko
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Paper Abstract

Reflectance and fluorescence spectroscopy are successfully used for skin disease diagnostics. Human skin optical parameters are defined by its turbid, scattering properties with nonuniform absorption and fluorescence chromophores distribution, its multilayered structure, and variability under different physiological and pathological conditions. Theoretical modeling of light propagation in skin could improve the understanding of these conditions and may be useful in the interpretation of in vivo reflectance and autofluorescence spectra. In the present work the temporal behavior of in vivo reflectance and autofluorescence (excitation wavelength 337 nm) spectra of human skin under ultraviolet irradiation and external mechanical pressure were investigated. Experimental results and Monte Carlo modeling of light distribution in skin were compared and demonstrated good agreements. Combination of diffuse reflectance and autofluorescence measurements is a very promising technique for precise erythema and pigmentation of the human skin evaluation.

Paper Details

Date Published: 4 January 1995
PDF: 12 pages
Proc. SPIE 2324, Optical Biopsy and Fluorescence Spectroscopy and Imaging, (4 January 1995); doi: 10.1117/12.198712
Show Author Affiliations
Sergei R. Utz M.D., Rural Hygiene Institute (Russia)
Yurii P. Sinichkin, Saratov State Univ. (Russia)
Igor Victorovich Meglinski, Saratov State Univ. (Russia)
Helena A. Pilipenko, Saratov State Univ. (Russia)

Published in SPIE Proceedings Vol. 2324:
Optical Biopsy and Fluorescence Spectroscopy and Imaging
Rinaldo Cubeddu; Renato Marchesini; Serge R. Mordon; Katarina Svanberg M.D.; Herbert H. Rinneberg; Georges A. Wagnieres, Editor(s)

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