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Proceedings Paper

Absorption spectra of photosensitizers detected in vivo in tumor bearing mice
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Paper Abstract

The absorption spectrum of disulphonated Aluminum Phthalocyanine (AlS2Pc) was measured in vivo in a murine tumor model by time-resolved reflectance (TRR). Mice bearing the L1210 leukemia were administered intraperitoneally 2.5 mg/kg body weight of AlS2Pc. Reflectance measurements were performed in the 650-695 nm range before and 4 h after the drug administration. The absorption coefficient at each wavelength was obtained by fitting the experimental curve using the diffusion equation. The spectrum of the photosensitizer was obtained as a difference between the absorption of treated and untreated mice. The absorption spectrum of AlS2Pc was peaked at 685 nm, showing a red-shift of approximately 15 nm with respect to the spectrum in aqueous solution.

Paper Details

Date Published: 4 January 1995
PDF: 6 pages
Proc. SPIE 2324, Optical Biopsy and Fluorescence Spectroscopy and Imaging, (4 January 1995); doi: 10.1117/12.198707
Show Author Affiliations
Rinaldo Cubeddu, Politecnico di Milano (Italy)
Gianfranco L. Canti, Univ. di Milano (Italy)
Antonio Pifferi, Politecnico di Milano (Italy)
Paola Taroni, Politecnico di Milano (Italy)
Gianluca Valentini, Politecnico di Milano (Italy)

Published in SPIE Proceedings Vol. 2324:
Optical Biopsy and Fluorescence Spectroscopy and Imaging
Rinaldo Cubeddu; Renato Marchesini; Serge R. Mordon; Katarina Svanberg M.D.; Herbert H. Rinneberg; Georges A. Wagnieres, Editor(s)

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