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Proceedings Paper

Two-dimensional computer simulations for real-time irradiation planning of laser-induced interstitial thermotherapy (LITT)
Author(s): Andre Roggan; Gerhard J. Mueller
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Paper Abstract

A computer model is presented enabling the determination of optimized laser parameters in advance of a LITT treatment. Besides, a real-time simulation of the spatial temperature- and damage distribution can be performed during the treatment. Input parameters for the simulation are the specific optical and thermal properties of the tissue. The optical properties of human liver and human prostate were measured at 850 nm and 1064 nm using a double- integrating sphere technique and inverse Monte-Carlo simulations. The thermal tissue properties were calculated from the individual water contents. The calculation of the spatial intensity distribution is carried out by performing a fast three-dimensional Monte-Carlo simulation in small time steps. The change of the optical tissue properties during the process of coagulation is taken into account. The corresponding temperature distribution is calculated by a numerical solution of the two-dimensional bio-heat transport equation in cylindrical geometry. Finally the degree of tissue damage is determined by solving the Arrhenius formulas numerically. Blood perfusion of the tissue can be considered as an internal cooling effect. Comparison of the calculated temperature behavior with experimental data shows good agreement.

Paper Details

Date Published: 23 December 1994
PDF: 11 pages
Proc. SPIE 2327, Medical Applications of Lasers II, (23 December 1994); doi: 10.1117/12.197569
Show Author Affiliations
Andre Roggan, Laser-Medizin-Zentrum GmbH (Germany)
Gerhard J. Mueller, Laser-Medizin-Zentrum GmbH (Germany)

Published in SPIE Proceedings Vol. 2327:
Medical Applications of Lasers II
Stephen G. Bown; J. Escourrou; Frank Frank; Herbert J. Geschwind M.D.; Guilhem Godlewski M.D.; Frederic Laffitte; Hans H. Scherer M.D., Editor(s)

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