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Proceedings Paper

In vivo optical coherence tomography of human skin microstructure
Author(s): Alexander M. Sergeev; Valentin M. Gelikonov; Grigory V. Gelikonov; Felix I. Feldchtein; Kirill I. Pravdenko; Dmitry V. Shabanov; Natalia D. Gladkova; Vitaly Pochinko; V. Zhegalov; G. Dmitriev; I. Vazina; Galina P. Petrova; Nikolai K. Nikulin
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Paper Abstract

A compact effective optical coherence tomography (OCT) system is presented. It contains approximately equals 0.3 mW superluminescent diode with spectral width 30 nm FWHM (providing approximately equals 15 micrometers longitudinal resolution) and fiber interferometer with integrated longitudinal scanning. The dynamic range 60 dB allows to observe structure of human skin in vivo up to 1.5 mm in depth. A comparison of obtained tomographs with data of histologic analysis of the same samples of the skin have been carried out to identify the observed structures and determine their optical properties. This technique allows one to perform noncontact, noninvasive diagnostic of early stages of different pathological state of the skin, to measure the burn depth and to observe the process of the recovery. Unlike scanning confocal microscopy, OCT is more suitable for an endoscopic investigation of the mucous membranes of hollow organs. Possible diagnostic applications include dermatology, gastroenterology, gynecology, urology, oncology, othorinolaryngology, transplantology. The most promising features are the potential possibility of differential diagnosis of precancer and various types of cancer, estimation of the invasion depth, differential diagnosis of inflammation and dystrophic processes, control of radical operative treatment.

Paper Details

Date Published: 22 December 1994
PDF: 7 pages
Proc. SPIE 2328, Biomedical Optoelectronic Devices and Systems II, (22 December 1994); doi: 10.1117/12.197520
Show Author Affiliations
Alexander M. Sergeev, Institute of Applied Physics (Russia)
Valentin M. Gelikonov, Institute of Applied Physics (Russia)
Grigory V. Gelikonov, Institute of Applied Physics (Russia)
Felix I. Feldchtein, Institute of Applied Physics (Russia)
Kirill I. Pravdenko, Institute of Applied Physics (Russia)
Dmitry V. Shabanov, Institute of Applied Physics (Russia)
Natalia D. Gladkova, Nizhny Novgorod Medical Unvi. (Russia)
Vitaly Pochinko, Nizhny Novgorod Regional Hospital (Russia)
V. Zhegalov, Nizhny Novgorod Institute of Orthopedy and Traumatology (Russia)
G. Dmitriev, Nizhny Novgorod Institute of Orthopedy and Traumatology (Russia)
I. Vazina, Nizhny Novgorod Institute of Orthopedy and Traumatology (Russia)
Galina P. Petrova, Nizhny Novgorod Skin Diseases Institute (Russia)
Nikolai K. Nikulin, Nizhny Novgorod Skin Diseases Institute (Russia)

Published in SPIE Proceedings Vol. 2328:
Biomedical Optoelectronic Devices and Systems II
Nathan I. Croitoru; Norbert Kroo; Mitsunobu Miyagi; Riccardo Pratesi; Juergen M. Wolfrum, Editor(s)

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